Active ingredientChlorobutanolCat. No. P-C135-001CAS 57-15-8
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Pharmacopoeial impurity · Chlorobutanol family
Pharmaceutical analytical standardChlorobutanol EP Impurity A
Synonyms: Chloroform, Chloroformum, Trichloromethane, Trichlormethan, Trichloroform, Formyl trichloride, Methane, trichloro-, Methenyl trichloride, Methyl trichloride, Methane trichloride, Chloroforme, Triclorometano, Cloroformio, Trichloormethaan, Chloroform bp, Methylidyne trichloride, CHLOROFORMWith Amylene, CHLOROFORMWith Ethanol, Chloroform CHCl3, Chlorform, Chloroforrn, Cloroform, Trichlormethane, d-chloroform, Chloroform SG, Trichloro(2H)methane, Trichloromethane, 9CI, Chloroform, ethanol-free, Chloroformium pro narcosi, Trichlormethan/Chloroform, Chloroform Stab. in 20 ppm Amylene, Chloroform 100 microg/mL in Methanol, Chloroform 5000 microg/mL in Methanol, Trichloromethane 10 microg/mL in Methanol, Trichloromethane 100 microg/mL in Methanol, Trichloromethane 5000 microg/mL in Methanol
- Cat. No.
- P-C135-002
- CAS
- 67-66-3
- Alternative CAS
- 2146-66-9 (lithium salt)
- 61414-06-0 (hydrate)
- 14478-07-0 (alternative CAS, same compound)
- Formula
- CHCl3
- Molecular weight
- 119.37 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Chlorobutanol
A trichlorinated alcohol synthesised in 1881 by German chemist Conrad Willgerodt by reacting chloroform with acetone: it is used mainly as an antimicrobial preservative in medicines and cosmetics and also has mild sedative and local anaesthetic properties.
Did you know?It smells like camphor and has an unusual talent: it can make sea urchin eggs develop without fertilisation, by parthenogenesis, up to the larval stage.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Chlorobutanol family
Active ingredientChlorobutanolCat. No. P-C135-001CAS 57-15-8
Active ingredientChlorobutanol HemihydrateCat. No. P-C135-003CAS 6001-64-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.