Active ingredientChlorothiazideCat. No. P-C138-001CAS 58-94-6
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Stable isotope labelled · Chlorothiazide family
Pharmaceutical analytical standardChlorothiazide-13C,15N2
Synonyms: Hydrochlorothiazide EP Impurity A-13C,15N2, 6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-(15N)sulfonamide, Chlorothiazide-(1)(3)C,(1)N2
- Cat. No.
- P-C138-002
- CAS
- 1189440-79-6
- Alternative CAS
- 58-94-6 (unlabelled form)
- 7085-44-1 (unlabelled form, sodium salt)
- 17278-61-4 (unlabelled form, hydrochloride)
- Formula
- C6¹³CH6ClN¹⁵N2O4S2
- Molecular weight
- 298.69 g/mol
- Category
- Stable isotope labelled
Family: Chlorothiazide
The first approved thiazide diuretic, descended from the sulfonamide line and on the market since 1958: it increases the excretion of salt and water in the urine and marked a turning point in the treatment of hypertension and of oedema from heart failure.
Did you know?Karl Beyer, James Sprague, John Baer and Frederick Novello, the four American researchers who developed the thiazides, received a special Lasker Award for this discovery in 1975.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Chlorothiazide family
Active ingredientChlorothiazideCat. No. P-C138-001CAS 58-94-6Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.