Active ingredientCinnarizineCat. No. P-C171-001CAS 298-57-7
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Pharmacopoeial impurity · Cinnarizine family
Pharmaceutical analytical standardCinnarizine EP Impurity A
Synonyms: 1-(Diphenylmethyl)piperazine, Benzhydrylpiperazine, 1-benzhydrylpiperazine, Norcyclizine, N-(Diphenylmethyl)piperazine, Piperazine, 1-(diphenylmethyl)-, NSC 35536, Diphenylmethylpiperazine, N-Benzhydrylpiperazine, Normethylcyclizine, Cinnarizine impurity a, Benzhydrylpiperazin, Diphenylmethylpiperazin, Cinnarizine metabolite M1, Benzhydrylpiperazine 1-(Diphenylmethyl)piperazine
- Cat. No.
- P-C171-002
- CAS
- 841-77-0
- Alternative CAS
- 56609-03-1 (hydrochloride)
- 83918-73-4 (acetate)
- 1588441-06-8 (hydrate)
- Formula
- C17H20N2
- Molecular weight
- 252.36 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Cinnarizine
An antihistamine and calcium channel blocker of the diphenylmethylpiperazine family, synthesised in 1955: it is used against nausea and vomiting from motion sickness, vertigo and Ménière's disease.
Did you know?Its name combines the cinnamyl group in its molecule, named after cinnamon, with the -rizine suffix used for antihistamines and vasodilators.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Cinnarizine family
Active ingredientCinnarizineCat. No. P-C171-001CAS 298-57-7
Pharmacopoeial impurityCinnarizine EP Impurity BCat. No. P-C171-003CAS 750512-44-8
Pharmacopoeial impurityCinnarizine EP Impurity CCat. No. P-C171-004CAS 95062-18-3
Pharmacopoeial impurityCinnarizine EP Impurity DCat. No. P-C171-005CAS 1415587-79-9
Pharmacopoeial impurityCinnarizine EP Impurity ECat. No. P-C171-006CAS 216581-01-0
Isotopically labelledCinnarizine-d8Cat. No. P-C171-007CAS 1185242-27-6
NitrosamineN-Nitroso Cinnarizine EP Impurity ACat. No. P-C171-008CAS 1698-25-5
ImpurityCinnarizine Impurity 1 DihydrochlorideCat. No. P-C171-009CAS 88185-31-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.