Active ingredient · Cocarboxylase family
Pharmaceutical analytical standardCocarboxylase
Synonyms: Cocarboxylase tetrahydrate, Thiamine diphosphate free ester tetrahydrate
- Cat. No.
- P-C236-001
- CAS
- 68684-55-9
- Alternative CAS
- 154-87-0 (hydrochloride)
- Formula
- C12H26N4O11P2S
- Molecular weight
- 496.36 g/mol
- Category
- Active ingredient (API)
The active form of vitamin B1, also called thiamine pyrophosphate: a coenzyme present in all living things, essential to key enzymes of sugar metabolism such as pyruvate dehydrogenase and transketolase.
Did you know?In 1937 biochemists Lohmann and Schuster showed that this form of thiamine with two phosphate groups is the cofactor that allows carbon dioxide to be removed from pyruvate.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
Shipped under controlled temperature when the molecule requires it.
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Sent with every order.
Follow your shipment live, from our warehouse to your lab.
Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.