Active ingredientDabrafenibCat. No. P-D002-001CAS 1195765-45-7
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Impurity or related compound · Dabrafenib family
Pharmaceutical analytical standardDabrafenib N2-Oxide
Synonyms: Dabrafenib Impurity 14, N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-3-oxido-1,3-thiazol-3-ium-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
- Cat. No.
- P-D002-034
- CAS
- 3052138-43-6
- Alternative CAS
- N/A
- Formula
- C23H20F3N5O3S2
- Molecular weight
- 535.56 g/mol
- Category
- Impurity or related compound
Family: Dabrafenib
An inhibitor of the mutated BRAF protein, approved in the United States in 2013 for advanced melanoma with the BRAF V600E mutation and later extended to other tumours with the same alteration.
Did you know?Because the tumour learns to get round it within a few months, since 2014 it has been used together with trametinib, which blocks the MEK protein just downstream of BRAF: a double block on the same signalling pathway.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Dabrafenib family
Active ingredientDabrafenibCat. No. P-D002-001CAS 1195765-45-7
Active ingredientDabrafenib MesylateCat. No. P-D002-002CAS 1195768-06-9
Isotopically labelledDabrafenib-d9Cat. No. P-D002-003CAS 1423119-98-5
Impurity2,2-DimethylpropanethioamideCat. No. P-D002-004CAS 630-22-8
Impurity2,6-Difluorobenzenesulfonic acidCat. No. P-D002-005CAS 686258-75-3
Impurity2,6-Difluorobenzenesulfonyl fluorideCat. No. P-D002-006CAS 447460-43-7
Impurity2-Chloro-4-methylpyrimidineCat. No. P-D002-007CAS 13036-57-2
ImpurityCarboxy DabrafenibCat. No. P-D002-008CAS 1195873-54-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.