Active ingredientPiperaquine PhosphateCat. No. P-P125-001CAS 85547-56-4
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Impurity or related compound · Piperaquine family
Pharmaceutical analytical standardDesarylpiperaquine
Synonyms: 7-Chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline, Piperaquine Impurity B, Quinoline, 7-chloro-4-(4-(3-(1-piperazinyl)propyl)-1-piperazinyl)-
- Cat. No.
- P-P125-013
- CAS
- 4039-00-3
- Alternative CAS
- N/A
- Formula
- C20H28ClN5
- Molecular weight
- 373.93 g/mol
- Category
- Impurity or related compound
Family: Piperaquine
A bisquinoline antimalarial synthesised in the 1960s and long used in China; today it is given together with dihydroartemisinin in a combination therapy against Plasmodium falciparum malaria.
Did you know?After declining in the 1980s it was rediscovered as an ideal partner for artemisinin derivatives: these clear the parasites quickly, while piperaquine stays in the blood for weeks and finishes the job.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Piperaquine family
Active ingredientPiperaquine PhosphateCat. No. P-P125-001CAS 85547-56-4
Pharmacopoeial impurityPiperaquine Phosphate USP Related Compound CCat. No. P-P125-002CAS 918879-09-1
MetabolitePiperaquine Metabolite 1Cat. No. P-P125-003
Isotopically labelledPiperaquine N-Oxide-d6Cat. No. P-P125-007
Isotopically labelledPiperaquine-d16Cat. No. P-P125-008
NitrosamineN-Nitroso Piperaquine Impurity ACat. No. P-P125-009CAS 32863-63-1
ImpurityPiperaquine Impurity ECat. No. P-P125-010CAS 86486-21-7
Impurity1,4-Bis(7-chloroquinolin-4-yl)piperazineCat. No. P-P125-011CAS 31502-87-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.