Active ingredientLenvatinibCat. No. P-L034-001CAS 417716-92-8
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Impurity or related compound · Lenvatinib family
Pharmaceutical analytical standardDescyclopropylcarbamoyl Lenvatinib
Synonyms: 4-(4-Amino-3-chlorophenoxy)-7-methoxy-6-quinolinecarboxamide, 4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide, Lenvatinib Impurity C, Lenvatinib Impurity LFS-H
- Cat. No.
- P-L034-010
- CAS
- 417722-93-1
- Alternative CAS
- N/A
- Formula
- C17H14ClN3O3
- Molecular weight
- 343.77 g/mol
- Category
- Impurity or related compound
Family: Lenvatinib
An oral multi-tyrosine kinase inhibitor, targeting VEGF, FGF, PDGF, RET and KIT receptors, that curbs the growth of tumours and their blood vessels: approved in 2015 for differentiated thyroid cancer, it was later extended to other solid tumours.
Did you know?Structural studies of the drug bound to its target revealed an unusual docking mode: it fills the ATP site with its quinoline part and anchors to a neighbouring region with a small cyclopropane ring.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Lenvatinib family
Active ingredientLenvatinibCat. No. P-L034-001CAS 417716-92-8
Active ingredientLenvatinib MesylateCat. No. P-L034-002CAS 857890-39-2
Isotopically labelledLenvatinib-d4Cat. No. P-L034-003CAS 2264050-65-7
Isotopically labelledLenvatinib-d5Cat. No. P-L034-004
ImpurityLenvatinib Impurity 1Cat. No. P-L034-006CAS 2380197-89-5
ImpurityLenvatinib Impurity 2Cat. No. P-L034-007CAS 253801-34-2
ImpurityDescyclopropyl LenvatinibCat. No. P-L034-008CAS 417719-51-8
ImpurityDeschloro LenvatinibCat. No. P-L034-009CAS 417714-14-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.