Active ingredientNarazaciclibCat. No. P-N023-001CAS 1357470-29-1
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Stable isotope labelled · Narazaciclib family
Pharmaceutical analytical standardDesmethyl Narazaciclib-d8
- Cat. No.
- P-N023-002
- CAS
- N/A
- Alternative CAS
- 2419274-38-5 (unlabelled form)
- Formula
- C23H17D8N7O
- Molecular weight
- 423.55 g/mol
- Category
- Stable isotope labelled
Family: Narazaciclib
An experimental multi-kinase inhibitor, active mainly on the CDK4 and CDK6 kinases that regulate the cell cycle, but also on NUAK1/ARK5 and CSF1R: it has been studied against cancer in phase 1 trials run in the US and China.
Did you know?It is described as able to cross the blood-brain barrier: it accumulates at high levels in the brain and in brain tumours, and in the laboratory it slows the proliferation of U87 glioma cells.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Narazaciclib family
Active ingredientNarazaciclibCat. No. P-N023-001CAS 1357470-29-1
ImpurityDesmethyl NarazaciclibCat. No. P-N023-005CAS 2419274-38-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.