Active ingredientDifelikefalinCat. No. P-D109-001CAS 1024828-77-0
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Impurity or related compound · Difelikefalin family
Pharmaceutical analytical standardDifelikefalin Impurity 11 Hydrochloride
Synonyms: (2S)-2-[[1-[(2S)-2-Azaniumyl-3-phenylpropanoyl]piperidine-4-carbonyl]amino]-3-phenylpropanoate hydrochloride
- Cat. No.
- P-D109-015
- CAS
- 1281870-04-9
- Alternative CAS
- 957006-52-9 (free base)
- Formula
- C24H29N3O4·HCl
- Molecular weight
- 459.97 g/mol
- Category
- Impurity or related compound
Family: Difelikefalin
A kappa opioid receptor agonist that acts mainly outside the brain: approved in the United States in 2021, it is given intravenously for itching associated with chronic kidney disease in patients on haemodialysis.
Did you know?It is a small synthetic peptide made of D-amino acids, the mirror images of the natural ones: highly water-soluble, it does not readily cross into the brain.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Difelikefalin family
Active ingredientDifelikefalinCat. No. P-D109-001CAS 1024828-77-0
Isotopically labelledDifelikefalin-d10Cat. No. P-D109-002
Isotopically labelledDifelikefalin-d5 TriHClCat. No. P-D109-003
ImpurityDifelikefalin Impurity 1 DihydrochlorideCat. No. P-D109-004CAS 76508-73-1
ImpurityDifelikefalin EnantiomerCat. No. P-D109-005CAS 2742623-84-1
ImpurityDifelikefalin Impurity 2Cat. No. P-D109-006CAS 2219351-44-5
ImpurityDifelikefalin Impurity 3Cat. No. P-D109-007CAS 2219351-45-6
ImpurityDifelikefalin Impurity 4Cat. No. P-D109-008CAS 2219351-61-6Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.