Active ingredientDihydroergotamineCat. No. P-D121-001CAS 511-12-6
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Pharmacopoeial impurity · Dihydroergotamine family
Pharmaceutical analytical standardDihydroergotamine EP Impurity A
Synonyms: Ergotamine, Ergotamin, Ergonsvine, Ergotamina, Ergotaminum, NSC 95090, Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'-alpha)-, Ergo Kranit, Mono, Ergodryl, Gynergen, Ergomar, Ergotamine dried down 100 microg/mL
- Cat. No.
- P-D121-007
- CAS
- 113-15-5
- Alternative CAS
- N/A
- Formula
- C33H35N5O5
- Molecular weight
- 581.67 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Dihydroergotamine
A derivative of ergotamine synthesised in 1943 in Switzerland by Albert Hofmann and colleagues and approved in 1946: it is used for acute migraine attacks, as a nasal spray or by injection.
Did you know?It descends from ergotamine, the main alkaloid of the ergot fungus Claviceps purpurea, isolated in 1918 by Arthur Stoll; the prefix dihydro- means two extra hydrogen atoms in the molecule.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Dihydroergotamine family
Active ingredientDihydroergotamineCat. No. P-D121-001CAS 511-12-6
Isotopically labelledDihydro Ergotamine-13C-d3 MesylateCat. No. P-D121-002CAS 1356841-81-0
Impurity9,10-Dihydroergotamine N-OxideCat. No. P-D121-003CAS 84094-90-6
ImpurityDihydroergotamine Impurity 1Cat. No. P-D121-004
Pharmacopoeial impurityDihydroergotamine EP Impurity CCat. No. P-D121-006CAS 2881077-62-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.