Active ingredientDiquafosolCat. No. P-D149-001CAS 59985-21-6
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Impurity or related compound · Diquafosol family
Pharmaceutical analytical standardDiquafosol Impurity 1
Synonyms: [[(2R,3S,4R,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
- Cat. No.
- P-D149-005
- CAS
- 26184-65-6
- Alternative CAS
- 221169-12-6 (sodium salt)
- Formula
- C18H24N4O17P2
- Molecular weight
- 630.35 g/mol
- Category
- Impurity or related compound
Family: Diquafosol
A P2Y2 receptor agonist eye drop approved in Japan in 2010 for dry eye disease: it stimulates the secretion of water and mucins on the eye surface, stabilising the tear film.
Did you know?It was the world's first P2Y2 receptor agonist approved as an eye drop; chemically it is a dinucleotide, made of two uridines joined by a chain of four phosphates.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Diquafosol family
Active ingredientDiquafosolCat. No. P-D149-001CAS 59985-21-6
Impurity1-(3-Dimethylaminopropyl)-3-ethylureaCat. No. P-D149-003CAS 32897-26-0
Impurity1-(a-D-ribofuranosyl)uracilCat. No. P-D149-004CAS 3258-07-9
ImpurityDiquafosol Impurity 1 Disodium SaltCat. No. P-D149-006CAS 221169-12-6
ImpurityDiquafosol Impurity 2Cat. No. P-D149-009
ImpurityDiquafosol Impurity 3Cat. No. P-D149-010
ImpurityDiquafosol Impurity 4Cat. No. P-D149-011
ImpurityDiquafosol Impurity 5Cat. No. P-D149-012Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.