Active ingredientDiroximel FumarateCat. No. P-D151-001CAS 1577222-14-0
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Impurity or related compound · Diroximel family
Pharmaceutical analytical standardDiroximel Fumarate Impurity A
Synonyms: Bis(2-(2,5-dioxopyrrolidin-1-yl)ethyl) fumarate, Diroximel Fumarate Impurity 3, bis[2-(2,5-dioxopyrrolidin-1-yl)ethyl] (E)-but-2-enedioate
- Cat. No.
- P-D151-004
- CAS
- 2101811-40-7
- Alternative CAS
- N/A
- Formula
- C16H18N2O8
- Molecular weight
- 366.33 g/mol
- Category
- Impurity or related compound
Family: Diroximel
Diroximel fumarate is an oral fumarate that is rapidly converted in the body into monomethyl fumarate, the active form: approved in the United States in October 2019 and in Europe in 2021 for relapsing forms of multiple sclerosis.
Did you know?Fumarates in medicine began in Germany: in 1959 the chemist Walter Schweckendiek, who had psoriasis, proposed a link with fumaric acid and tested its esters on himself; they were later approved for psoriasis in 1994.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Diroximel family
Active ingredientDiroximel FumarateCat. No. P-D151-001CAS 1577222-14-0
Isotopically labelledDiroximel Fumarate-d4Cat. No. P-D151-002
ImpurityDiroximel Impurity 1Cat. No. P-D151-003CAS 2101811-42-9
ImpurityDiroximel Impurity 2Cat. No. P-D151-005CAS 2101811-41-8
ImpurityDiroximel Impurity 3 HydrochlorideCat. No. P-D151-006
ImpurityDiroximel Impurity 4Cat. No. P-D151-007![N-[2-Hydroxyethyl]succinimide](https://img.vitasanlabs.com/vsl-struct/P-D151-008.svg?v=41e934f030)
ImpurityN-[2-Hydroxyethyl]succinimideCat. No. P-D151-008CAS 18190-44-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.