Active ingredientDoxylamineCat. No. P-D186-001CAS 469-21-6
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Pharmacopoeial impurity · Doxylamine family
Pharmaceutical analytical standardDoxylamine EP Impurity A
Synonyms: Doxylamine pyridine-4-yl, N,N-dimethyl-2-(1-phenyl-1-pyridin-4-ylethoxy)ethanamine, Ethanamine, N,N-dimethyl-2-(1-phenyl-1-(4-pyridinyl)ethoxy)-, N,N-Dimethyl-2-(1-phenyl-1-(pyridin-4-yl)ethoxy)ethan-1-amine, N,N-Dimethyl-2-(1-phenyl-1-(4-pyridinyl)ethoxy)ethanamine, Doxylamine 4-Pyridinyl Isomer, Doxylamine Impurity A, Doxylamine pyridine-4-yl isomer, N,N-Dimethyl-2-((1RS)-1-phenyl-1-(pyridin-4-yl)ethoxy)ethanamine
- Cat. No.
- P-D186-003
- CAS
- 873407-01-3
- Alternative CAS
- 2731671-64-8 (succinate)
- 2575516-50-4 (succinate)
- Formula
- C17H22N2O
- Molecular weight
- 270.38 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Doxylamine
A first-generation ethanolamine antihistamine, described in the late 1940s: it is used against occasional insomnia and, together with vitamin B6, against nausea in pregnancy.
Did you know?It was discovered by chemist Nathan Sperber and colleagues. It easily crosses the barrier that protects the brain: this is why, like the other first-generation antihistamines, it has a sedative effect that makes it useful as a sleep aid.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Doxylamine family
Active ingredientDoxylamineCat. No. P-D186-001CAS 469-21-6
Active ingredientDoxylamine Hydrogen SuccinateCat. No. P-D186-002CAS 562-10-7
Pharmacopoeial impurityDoxylamine EP Impurity A DiHClCat. No. P-D186-004
Pharmacopoeial impurityDoxylamine EP Impurity A HClCat. No. P-D186-005
Pharmacopoeial impurityDoxylamine EP Impurity BCat. No. P-D186-006CAS 19490-92-7
Pharmacopoeial impurityDoxylamine Hydrogen Succinate EP Impurity A as Hydrogen SuccinateCat. No. P-D186-008CAS 2731671-64-8
Pharmacopoeial impurityDoxylamine Hydrogen Succinate EP Impurity B as HydrochlorideCat. No. P-D186-009CAS 879671-67-7
Pharmacopoeial impurityDoxylamine Hydrogen Succinate EP Impurity C as FumarateCat. No. P-D186-010CAS 2734096-32-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.