Active ingredientEmedastineCat. No. P-E032-001CAS 87233-61-2
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Pharmacopoeial impurity · Emedastine family
Pharmaceutical analytical standardEmedastine EP Impurity E
Synonyms: 2-(1,4-diazepan-1-yl)-1-(2-ethoxyethyl)benzimidazole, Emedastine impurity E
- Cat. No.
- P-E032-007
- CAS
- 101954-20-5
- Alternative CAS
- N/A
- Formula
- C16H24N4O
- Molecular weight
- 288.40 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Emedastine
A second-generation H1 antihistamine, a benzimidazole derivative, used as eye drops for seasonal allergic conjunctivitis: in this form it was approved in the United States and Europe in the late 1990s.
Did you know?In Japan it started out as an antihistamine taken by mouth, for allergic rhinitis and urticaria; elsewhere it is known almost only as eye drops.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Emedastine impurity E CRSEP Y0000512
More products in the Emedastine family
Active ingredientEmedastineCat. No. P-E032-001CAS 87233-61-2
Pharmacopoeial impurityEmedastine EP Impurity ACat. No. P-E032-003CAS 101953-61-1
Pharmacopoeial impurityEmedastine EP Impurity BCat. No. P-E032-004CAS 87233-54-3
Pharmacopoeial impurityEmedastine EP Impurity C HClCat. No. P-E032-005
Pharmacopoeial impurityEmedastine EP Impurity D DiHClCat. No. P-E032-006
Pharmacopoeial impurityEmedastine EP Impurity FCat. No. P-E032-008
Isotopically labelledEmedastine-13C-d3Cat. No. P-E032-009
Isotopically labelledEmedastine-13C-d3 FumarateCat. No. P-E032-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.