Active ingredientEsketamine HydrochlorideCat. No. P-E093-001CAS 33643-47-9
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Pharmacopoeial impurity · Esketamine family
Pharmaceutical analytical standardEsketamine Hydrochloride EP Impurity D Hydrochloride
Synonyms: Arketamine HCl, Ketamine hydrochloride, L-, Arketamine hydrochloride, Ketamine hydrochloride, r-, r-(-)-ketamine hydrochloride, Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, hydrochloride, (R)-, Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, hydrochloride, (+)-, L-Ketamine hydrochloride
- Cat. No.
- P-E093-004
- CAS
- 33795-24-3
- Alternative CAS
- 33643-49-1 (free base)
- Formula
- C13H16ClNO·HCl
- Molecular weight
- 274.19 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Esketamine
The S-form of ketamine, one of its two mirror-image versions: introduced as an anaesthetic in Germany in 1997, in 2019 it was approved in the United States as a nasal spray, together with an oral antidepressant, for treatment-resistant depression.
Did you know?It binds NMDA glutamate receptors more strongly than ordinary ketamine, which is an equal mixture of the two mirror-image forms.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Esketamine family
Active ingredientEsketamine HydrochlorideCat. No. P-E093-001CAS 33643-47-9
Pharmacopoeial impurityEsketamine EP Impurity DCat. No. P-E093-002CAS 6740-88-1
Pharmacopoeial impurityEsketamine Hydrochloride EP Impurity DCat. No. P-E093-003CAS 33643-49-1
Active ingredientEsketamineCat. No. P-E093-005CAS 33643-46-8
ImpurityDeschloroketamineCat. No. P-E093-006CAS 7063-30-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.