Active ingredientUmeclidinium BromideCat. No. P-U006-001CAS 869113-09-7
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Impurity or related compound · Umeclidinium family
Pharmaceutical analytical standardEthyl Quinuclidine-4-carboxylate
Synonyms: Ethyl 1-azabicyclo(2.2.2)octane-4-carboxylate, ethyl 1-azabicyclo[2.2.2]octane-4-carboxylate, Umeclidinium impurity 25
- Cat. No.
- P-U006-011
- CAS
- 22766-68-3
- Alternative CAS
- 22766-67-2 (hydrochloride)
- Formula
- C10H17NO2
- Molecular weight
- 183.25 g/mol
- Category
- Impurity or related compound
Family: Umeclidinium
A long-acting antimuscarinic inhaled for the maintenance treatment of COPD: approved in the United States in 2013 in a single inhaler with vilanterol, and on its own in 2014.
Did you know?It is a quinuclidine derivative with a positively charged nitrogen, as the ending -ium suggests: the part of the dose swallowed during inhalation is practically not absorbed from the gut.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Umeclidinium family
Active ingredientUmeclidinium BromideCat. No. P-U006-001CAS 869113-09-7
MetaboliteUmeclidinium M-33 Metabolite BromideCat. No. P-U006-002
Isotopically labelledUmeclidinium Bromide-d5Cat. No. P-U006-003
Isotopically labelledUmeclidinium-d7 BromideCat. No. P-U006-004
ImpurityUmeclidinium Impurity 1Cat. No. P-U006-005CAS 461648-39-5
ImpurityUmeclidinium Impurity 2Cat. No. P-U006-006CAS 2253743-32-5
ImpurityUmeclidinium Impurity 3Cat. No. P-U006-007CAS 2253743-33-6
ImpurityUmeclidinium Impurity 4 BromideCat. No. P-U006-008CAS 869113-10-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.