Active ingredientEzetimibeCat. No. P-E150-001CAS 163222-33-1
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Impurity or related compound · Ezetimibe family
Pharmaceutical analytical standardEzetimibe Dehydroxy Impurity
Synonyms: 3-Dehydroxy Ezetimibe, Ezetimibe Dehydoxy Impurity, Ezetimibe impurity
- Cat. No.
- P-E150-055
- CAS
- 204589-58-2
- Alternative CAS
- N/A
- Formula
- C24H21F2NO2
- Molecular weight
- 393.43 g/mol
- Category
- Impurity or related compound
Family: Ezetimibe
It lowers cholesterol by blocking its absorption in the gut, and was approved in 2002. It is often combined with a statin, which instead blocks cholesterol production in the liver.
Did you know?It was found while searching for a medicine with a different mechanism: its real target, the NPC1L1 protein, was only identified in 2004, two years after approval.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ezetimibe family
Active ingredientEzetimibeCat. No. P-E150-001CAS 163222-33-1
Active ingredientEzetimibe DiacetateCat. No. P-E150-002CAS 163380-20-9
MetaboliteEzetimibe Hydroxy GlucuronideCat. No. P-E150-003CAS 536709-33-8
MetaboliteEzetimibe Phenoxy GlucuronideCat. No. P-E150-004CAS 190448-57-8
Isotopically labelled3-O-Acetyl Ezetimibe-d4Cat. No. P-E150-005CAS 1217642-08-4
Isotopically labelledEzetimibe Diacetate-d4Cat. No. P-E150-006CAS 1217861-13-6
Isotopically labelledEzetimibe phenoxy Glucuronide-d4Cat. No. P-E150-007CAS 1426174-41-5
Isotopically labelledEzetimibe-13C6Cat. No. P-E150-008CAS 438624-68-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.