Active ingredientFolinic AcidCat. No. P-F109-001CAS 58-05-9
Drag to rotate
Impurity or related compound · Folinic Acid family
Pharmaceutical analytical standardFolinic Acid Impurity 5
- Cat. No.
- P-F109-027
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C21H23N7O8
- Molecular weight
- 501.46 g/mol
- Category
- Impurity or related compound
Family: Folinic Acid
The active form of folic acid (5-formyltetrahydrofolate), in use since the 1950s: it protects healthy cells after high-dose methotrexate and enhances the effect of 5-fluorouracil in the treatment of colorectal cancer.
Did you know?It was described in 1948 as a growth factor needed by the bacterium Leuconostoc citrovorum, the 'citrovorum factor': hence its other name, leucovorin.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Folinic Acid family
Active ingredientFolinic AcidCat. No. P-F109-001CAS 58-05-9
Pharmacopoeial impurity(6R)-Folinic AcidCat. No. P-F109-002CAS 73951-54-9
Pharmacopoeial impurityCalcium Folinate EP Impurity I (Mixture of Diastereomers)Cat. No. P-F109-003CAS 3432-99-3
Pharmacopoeial impurityCalcium Folinate EP Impurity I Disodium Salt (Folitixorin Disodium Salt)Cat. No. P-F109-004CAS 133978-76-4
Pharmacopoeial impurityFolinic Acid EP Impurity B (Mixture of Diastereomers)Cat. No. P-F109-005CAS 98814-60-9
Pharmacopoeial impurityFolinic Acid EP Impurity D Disodium SaltCat. No. P-F109-006
Pharmacopoeial impurityCalcium Levofolinate EP Impurity ECat. No. P-F109-007CAS 944737-05-7
Pharmacopoeial impurityFolinic Acid EP Impurity G Disodium Salt (7,8-Dihydrofolic Acid Disodium Salt)Cat. No. P-F109-008CAS 1809246-78-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.