Active ingredientForetinibCat. No. P-F113-001CAS 849217-64-7
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Impurity or related compound · Foretinib family
Pharmaceutical analytical standardForetinib Impurity 1
- Cat. No.
- P-F113-004
- CAS
- N/A
- Alternative CAS
- 2143459-80-5 (other form)
- Formula
- C36H36F2N4O6
- Molecular weight
- 658.70 g/mol
- Category
- Impurity or related compound
Family: Foretinib
An experimental inhibitor of the MET and VEGFR-2 tyrosine kinases, the receptors for the growth factors HGF and VEGF: it was studied against cancer in about ten phase II trials, but by 2015 its development appeared to have been discontinued.
Did you know?Its structure is very similar to that of cabozantinib, another kinase inhibitor that did gain approval in the US: two near-twin molecules with different fates.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Foretinib family
Active ingredientForetinibCat. No. P-F113-001CAS 849217-64-7
Isotopically labelledForetinib-13C,d3Cat. No. P-F113-003
ImpurityForetinib Impurity 2Cat. No. P-F113-005Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.