Active ingredientGemcitabineCat. No. P-G023-001CAS 95058-81-4
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Impurity or related compound · Gemcitabine family
Pharmaceutical analytical standardGemcitabine Impurity 32
Synonyms: [(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl benzoate
- Cat. No.
- P-G023-056
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C16H15F2N3O5
- Molecular weight
- 367.31 g/mol
- Category
- Impurity or related compound
Family: Gemcitabine
A nucleoside analogue of deoxycytidine carrying two fluorine atoms, synthesised in the early 1980s and approved in 1995; it is a chemotherapy drug for cancers of the pancreas, lung, bladder, ovary and breast.
Did you know?It was created in chemist Larry Hertel's laboratory as an antiviral, but preclinical tests showed it could kill leukaemia cells: so it changed course and became an anticancer drug.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Gemcitabine family
Active ingredientGemcitabineCat. No. P-G023-001CAS 95058-81-4
Pharmacopoeial impurityGemcitabine EP Impurity BCat. No. P-G023-003CAS 95058-85-8
Pharmacopoeial impurityGemcitabine EP Impurity B Hydrochloride (Gemcitabine alpha-Isomer Hydrochloride)Cat. No. P-G023-004CAS 122111-05-1
Pharmacopoeial impurityGemcitabine EP Impurity CCat. No. P-G023-005CAS 114248-23-6
Isotopically labelledGemcitabine EP Impurity C-13C-15N2Cat. No. P-G023-009CAS 1233921-75-9
Isotopically labelledGemcitabine-13C-15N2Cat. No. P-G023-011CAS 1233921-74-8
ImpurityGemcitabine Impurity 1Cat. No. P-G023-014CAS 294177-31-4
ImpurityGemcitabine 3',5'-DibenzoateCat. No. P-G023-015CAS 134790-39-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.