Active ingredientImatinibCat. No. P-I026-001CAS 152459-95-5
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Impurity or related compound · Imatinib family
Pharmaceutical analytical standardImatinib Impurity 28
Synonyms: N-(2-Methyl-5-nitrophenyl)-4-pyridin-4-ylpyrimidin-2-amine
- Cat. No.
- P-I026-059
- CAS
- 1232063-00-1
- Alternative CAS
- N/A
- Formula
- C16H13N5O2
- Molecular weight
- 307.31 g/mol
- Category
- Impurity or related compound
Family: Imatinib
An inhibitor of BCR-ABL tyrosine kinase, the abnormal protein that drives chronic myeloid leukaemia. It was approved in the United States in 2001 in record time, after clinical trials led by oncologist Brian Druker.
Did you know?Its target arises from the Philadelphia chromosome, discovered in 1960 by Peter Nowell and David Hungerford and named after the city where they worked.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Imatinib family
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Pharmacopoeial impurityImatinib EP Impurity CCat. No. P-I026-004CAS 404844-02-6
Pharmacopoeial impurityImatinib EP Impurity D ChlorideCat. No. P-I026-006
Pharmacopoeial impurityImatinib EP Impurity FCat. No. P-I026-007CAS 152460-10-1
Pharmacopoeial impurityImatinib EP Impurity HCat. No. P-I026-008CAS 350-03-8
Pharmacopoeial impurityImatinib EP Impurity JCat. No. P-I026-009CAS 571186-91-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.