Active ingredientIvabradine HClCat. No. P-I106-001CAS 148849-67-6
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Impurity or related compound · Ivabradine family
Pharmaceutical analytical standardIvabradine Impurity 18 Hydrochloride
Synonyms: 1-[(7S)-3,4-Dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]-N-methylmethanamine hydrochloride, Bicyclo(4.2.0)octa-1,3,5-triene-7-methanamine, 3,4-dimethoxy-N-methyl-, hydrochloride, (7S)-
- Cat. No.
- P-I106-038
- CAS
- 866783-13-3
- Alternative CAS
- 866783-12-2 (free base)
- Formula
- C12H17NO2·HCl
- Molecular weight
- 243.73 g/mol
- Category
- Impurity or related compound
Family: Ivabradine
It selectively slows the heartbeat by blocking the channels of the 'funny' current in the sinoatrial node, the heart's natural pacemaker. Approved in Europe in 2005, it is used in chronic stable angina and heart failure.
Did you know?The 'funny' current was discovered in 1979 in Oxford by the Italian Dario DiFrancesco and colleagues. It was named for its unusual properties: it is activated by hyperpolarisation and lets through both sodium and potassium.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ivabradine family
Active ingredientIvabradine HClCat. No. P-I106-001CAS 148849-67-6
Isotopically labelledIvabradine-d3Cat. No. P-I106-003CAS 1217977-70-2
Isotopically labelledIvabradine-d3 HydrochlorideCat. No. P-I106-004CAS 1217809-61-4
Isotopically labelledrac-N-Desmethyl Ivabradine-d6 HClCat. No. P-I106-006CAS 1346600-74-5
NitrosamineN-Nitroso Ivabradine Impurity 1Cat. No. P-I106-007
NitrosamineN-Nitroso Ivabradine Impurity 2Cat. No. P-I106-008
NitrosamineN-Nitroso-N-Desmethyl IvabradineCat. No. P-I106-009
ImpurityIvabradine intCat. No. P-I106-010CAS 148870-57-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.