Active ingredientIxazomibCat. No. P-I110-001CAS 1072833-77-2
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Impurity or related compound · Ixazomib family
Pharmaceutical analytical standardIxazomib Impurity 18
Synonyms: 2,5-Dichloro-N-[2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxoethyl]benzamide
- Cat. No.
- P-I110-027
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C14H18Cl2N2O3
- Molecular weight
- 333.21 g/mol
- Category
- Impurity or related compound
Family: Ixazomib
A proteasome inhibitor, blocking the system that disposes of proteins cells no longer need. Approved in the United States in 2015 and in Europe in 2016 for multiple myeloma, it is taken by mouth, unlike bortezomib, which must be injected.
Did you know?It contains a boron atom: it is a boronic acid built on the skeleton of the amino acid leucine, and it is taken as a citrate ester that quickly releases the active form in the body.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ixazomib family
Active ingredientIxazomibCat. No. P-I110-001CAS 1072833-77-2
Active ingredientIxazomib CitrateCat. No. P-I110-002CAS 1239908-20-3
NitrosamineN1-Nitroso Ixazomib CitrateCat. No. P-I110-004
NitrosamineN2-Nitroso Ixazomib CitrateCat. No. P-I110-005
Impurity(S)-Ixazomib CitrateCat. No. P-I110-006
Impurity(S)-Ixazomib TrimerCat. No. P-I110-007
ImpurityDeboronated IxazomibCat. No. P-I110-008CAS 2872629-73-5
ImpurityIxazomib Impurity 1Cat. No. P-I110-009CAS 1201903-02-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.