Active ingredientLapatinibCat. No. P-L017-001CAS 231277-92-2
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Impurity or related compound · Lapatinib family
Pharmaceutical analytical standardLapatinib Impurity 8
Synonyms: 5-[4-[4-[(3-Fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde
- Cat. No.
- P-L017-023
- CAS
- 746591-42-4
- Alternative CAS
- N/A
- Formula
- C26H18FN3O3
- Molecular weight
- 439.45 g/mol
- Category
- Impurity or related compound
Family: Lapatinib
An oral tyrosine kinase inhibitor that blocks two receptors at once, HER2 and EGFR; approved in the United States in 2007 and in Europe in 2008 for advanced HER2-positive breast cancer.
Did you know?While antibodies such as trastuzumab bind HER2 from outside the cell, lapatinib is a small molecule that enters the cell and switches the receptor off from the inside.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Lapatinib family
Active ingredientLapatinibCat. No. P-L017-001CAS 231277-92-2
ImpurityLapatinib Impurity 1Cat. No. P-L017-002
ImpurityLapatinib Impurity 2Cat. No. P-L017-003
Isotopically labelledLapatinib-d4Cat. No. P-L017-004CAS 1184264-15-0
Isotopically labelledLapatinib-d5Cat. No. P-L017-006
NitrosamineN-Nitroso LapatinibCat. No. P-L017-007
Impurity3-Chloro-4-(3-fluorobenzyloxy)anilineCat. No. P-L017-008CAS 202197-26-0
ImpurityLapatinib Impurity 3Cat. No. P-L017-009CAS 202196-46-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.