Active ingredientLetrozoleCat. No. P-L038-001CAS 112809-51-5
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Pharmacopoeial impurity · Letrozole family
Pharmaceutical analytical standardLetrozole EP Impurity B
Synonyms: 4,4',4''-Methanetriyltribenzonitrile, 4-[bis(4-cyanophenyl)methyl]benzonitrile, Letrozole impurity b (ep impurity), Letrozole impurity, 4,4',4''-methanetriyltribenzonitrile-, Letrozole impurity, 4,4',4''-methanetriyltribenzonitrile-(usp impurity), Letrozole specified impurity B, Letrozole Impurity B, Benzonitrile, 4,4',4''-methylidynetris-, ImpurityofLetrozole
- Cat. No.
- P-L038-003
- CAS
- 113402-31-6
- Alternative CAS
- N/A
- Formula
- C22H13N3
- Molecular weight
- 319.37 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Letrozole
A non-steroidal inhibitor of aromatase, the enzyme that makes oestrogens: patented in 1986 and approved in 1996, it is used against hormone-sensitive breast cancer in postmenopausal women.
Did you know?By lowering oestrogen it prompts the pituitary to release more follicle-stimulating hormone: for this reason, since the early 2000s, it has also been studied and used to induce ovulation in polycystic ovary syndrome.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Letrozole family
Active ingredientLetrozoleCat. No. P-L038-001CAS 112809-51-5
Pharmacopoeial impurityLetrozole EP Impurity ACat. No. P-L038-002CAS 112809-52-6
MetaboliteCarbinol Metabolite of LetrozoleCat. No. P-L038-004CAS 134521-16-7
Isotopically labelledLetrozole-d4Cat. No. P-L038-005CAS 1133712-96-5
Impurity4,4-(Bromomethylene)dibenzonitrileCat. No. P-L038-006CAS 69545-39-7
Impurity4,4-(Carbonohydrazonoyl)dibenzonitrileCat. No. P-L038-007CAS 64568-34-9
Impurity4,4-CarbonyldibenzonitrileCat. No. P-L038-008CAS 32446-66-5
Impurity4,4-DibromobenzophenoneCat. No. P-L038-009CAS 3988-03-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.