Active ingredientLevosimendanCat. No. P-L058-001CAS 141505-33-1
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Impurity or related compound · Levosimendan family
Pharmaceutical analytical standardLevosimendan Impurity 4
Synonyms: 6-(4-(ethylamino)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one, 3-[4-(ethylamino)phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
- Cat. No.
- P-L058-008
- CAS
- 52240-42-3
- Alternative CAS
- N/A
- Formula
- C13H17N3O
- Molecular weight
- 231.30 g/mol
- Category
- Impurity or related compound
Family: Levosimendan
A calcium sensitiser developed in Finland and first approved in Sweden in 2000 for acute heart failure: by binding troponin C it makes the heart more sensitive to calcium and strengthens contraction, while it widens blood vessels by opening potassium channels.
Did you know?The drug itself is cleared in about an hour, but one of its active metabolites has a half-life of about 80 hours: this is why the effects of a 24-hour infusion can last for several days.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Levosimendan family
Active ingredientLevosimendanCat. No. P-L058-001CAS 141505-33-1
NitrosamineN-Nitroso LevosimendanCat. No. P-L058-002
NitrosamineN-Nitroso Levosimendan Impurity 1Cat. No. P-L058-003
NitrosamineN-Nitroso Levosimendan Impurity 2Cat. No. P-L058-004
ImpurityLevosimendan Impurity 1Cat. No. P-L058-005CAS 1284376-94-8
ImpurityLevosimendan Impurity 2Cat. No. P-L058-006CAS 52241-03-9
ImpurityLevosimendan Impurity 3Cat. No. P-L058-007CAS 36725-26-5
ImpurityDextrosimendanCat. No. P-L058-009CAS 144238-75-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.