Active ingredientLifitegrastCat. No. P-L063-001CAS 1025967-78-5
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Impurity or related compound · Lifitegrast family
Pharmaceutical analytical standardLifitegrast Impurity 40
Synonyms: (2S)-2-[[2-(1-Benzofuran-6-carbonyl)-5,7-dichloro-1-oxoisoquinoline-6-carbonyl]amino]-3-(3-methylsulfonylphenyl)propanoic acid
- Cat. No.
- P-L063-059
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C29H20Cl2N2O8S
- Molecular weight
- 627.44 g/mol
- Category
- Impurity or related compound
Family: Lifitegrast
Eye drops for dry eye disease, approved in the United States in 2016: it mimics the docking site of the ICAM-1 protein and blocks the LFA-1 receptor on T lymphocytes, calming inflammation on the eye's surface.
Did you know?Many patients notice an unusual taste in the mouth after the drops: the solution probably drains through the tear ducts, which connect the eye to the nose and throat.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Lifitegrast family
Active ingredientLifitegrastCat. No. P-L063-001CAS 1025967-78-5
Isotopically labelledLifitegrast-d4Cat. No. P-L063-002
Isotopically labelledrac-Lifitegrast-d4Cat. No. P-L063-003
NitrosamineN-Nitroso LifitegrastCat. No. P-L063-004
Impurity1-Benzofuran-6-carboxylic acidCat. No. P-L063-005CAS 77095-51-3
ImpurityLifitegrast Impurity 1Cat. No. P-L063-006CAS 170097-67-3
ImpurityLifitegrast Impurity 2Cat. No. P-L063-007CAS 851784-82-2
ImpurityLifitegrast Impurity 3Cat. No. P-L063-008CAS 2605229-68-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.