Active ingredientMedronic AcidCat. No. P-M028-001CAS 1984-15-2
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Pharmacopoeial impurity · Medronic Acid family
Pharmaceutical analytical standardMedronic Acid EP Impurity A
Synonyms: Tris(1-methylethoxy)phosphane, Triisopropyl phosphite, tripropan-2-yl phosphite, Phosphorous acid, tris(1-methylethyl) ester, Triisopropoxyphosphine, Isopropyl phosphite, tri-, Phosphorous acid, triisopropyl ester, NSC 6516, Tri-i-propylphosphite, Tris(propan-2-yl) phosphite, Isopropyl phosphite, ((C3H7O)3P), Tris(isopropyl) phosphite
- Cat. No.
- P-M028-002
- CAS
- 116-17-6
- Alternative CAS
- N/A
- Formula
- C9H21O3P
- Molecular weight
- 208.24 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Medronic Acid
The smallest bisphosphonate, also known as methylene diphosphonate (MDP): bound to technetium-99m it is used in nuclear medicine for bone scans, to detect metastases and other changes in bone turnover.
Did you know?The technetium complex was described in 1975 by Gopal Subramanian and John McAfee of SUNY Upstate as a superior agent for skeletal imaging: images were already of high quality two hours after injection.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Medronic acid impurity A CRSEP Y0001107
More products in the Medronic Acid family
Active ingredientMedronic AcidCat. No. P-M028-001CAS 1984-15-2
Pharmacopoeial impurityMedronic Acid EP Impurity BCat. No. P-M028-003CAS 1660-95-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.