NitrosamineN-Nitroso Methylthioninium Chloride EP Impurity A ChlorideCat. No. P-M101-003
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Active ingredient · Methylthioninium family
Pharmaceutical analytical standardMethylthioninium Chloride
Synonyms: Methylene Blue, Swiss Blue, Chromosmon, Methylene Blue N, Methylene Blue BB, Urolene blue, Methylenium ceruleum, Methylene Blue chloride, Methylene Blue A, Methylene Blue B, Methylene Blue D, Methylene Blue G, Tetramethylene Blue, Calcozine Blue ZF, Methylene Blue BD, Methylene Blue BP, Methylene Blue BX, Methylene Blue BZ, Methylene Blue FZ, Methylene Blue GZ, Methylene Blue NZ, Methylene Blue SG, Methylene Blue SP, Methylene Blue ZF, Methylene Blue ZX, Methylthionine chloride, Methylenblau, Methylene Blue BBA, Methylene Blue BPC, Methylene Blue HGG, Methylene Blue IAD, Methylene Blue JFA, Sandocryl Blue BRL, Modr methylenova, Mitsui Methylene Blue, Methylthionium chloride, Leather Pure Blue HB, Ceruleum methylenum, Aizen Methylene Blue BH, Aizen Methylene Blue FZ, Methylenum coeruleum, Yamamoto Methylene Blue B, Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, Tetramethylthionine chloride, Yamamoto Methylene Blue ZF, Methylene Blue (Medicinal), Methylthionini chloridum, Methylene Blue I (Medicinal), Methylthioninii chloridum, Methylene Blue NF (Medicinal), Hidaco Methylene Blue Salt Free, Methylene Blue USP (Medicinal), Metiltioninio cloruro, Provayblue, Methylene Blue Chloride (Biological stain), Methylene Blue USP XII (Medicinal), Blue, Methylene, Blue, Urolene, Blue, Swiss, Blue N, Methylene, Tetramethylthionine chloride trihydrate, Desmoidpillen, Collubleu, Vitableu, Azul Metile, Blu di Metilene, Methylene Blue INJ, Methylenum Caeruleum, M-B Tabs, Ehrlichs reagent III, Rember, N-(7-(dimethylamino)-3H-phenothiazin-3-ylidene)-N-methylmethanaminium chloride, Phenothiazin-5-ium,7-bis(dimethylamino)-, chloride, Methylene blue usp, Loeffler's Methylene Blue
- Cat. No.
- P-M101-001
- CAS
- 61-73-4
- Alternative CAS
- 7060-82-4 (free base)
- 699015-82-2 (free base)
- 1001913-24-1 (free base)
- 91223-87-9 (sulfate)
- 7220-79-3 (hydrate)
- 32680-41-4 (hydrate)
- 1082603-14-2 (hydrate)
- 4727-46-2 (hydroiodide)
- 122965-43-9 (hydrate)
- 67183-68-0 (hydrate)
- 613-10-5 (hydrate)
- 6372-69-6 (hydrochloride zinc salt)
- 105504-42-5 (alternative CAS, same compound)
- 12262-49-6 (alternative CAS, same compound)
- 152071-32-4 (alternative CAS, same compound)
- 97130-83-1 (alternative CAS, same compound)
- 150645-86-6 (alternative CAS, same compound)
- Formula
- C16H18N3S·Cl·H2O
- Molecular weight
- 337.87 g/mol
- Category
- Active ingredient (API)
This is methylene blue, a dye of the phenothiazine family prepared in 1876 by the German chemist Heinrich Caro; in medicine it is used to treat methaemoglobinaemia.
Did you know?In 1891 Paul Guttmann and Paul Ehrlich used it to treat malaria: for this reason it is often described as the first fully synthetic drug in the history of medicine.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Methylthioninium chloride CRSEP M1800900
- Methylthioninium for system suitability CRSEP Y0001744
More products in the Methylthioninium family
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Active ingredientMethylthioninium Chloride HydrateCat. No. P-M101-004CAS 122965-43-9
ImpurityMethylthioninium Impurity 1Cat. No. P-M101-005
ImpurityMethylthioninium Impurity 2Cat. No. P-M101-006CAS 78338-22-4
ImpurityMethylthioninium Impurity 3 ChlorideCat. No. P-M101-007CAS 1242769-80-7
ImpurityMethylthioninium Impurity 4Cat. No. P-M101-008
ImpurityMethylthioninium Impurity 5Cat. No. P-M101-009CAS 126656-05-1
ImpurityMethylene Blue Stage 1Cat. No. P-M101-010CAS 43035-11-6Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.