Active ingredientMexiletineCat. No. P-M117-001CAS 31828-71-4
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Pharmacopoeial impurity · Mexiletine family
Pharmaceutical analytical standardMexiletine Hydrochloride EP Impurity A
Synonyms: Mexiletine Impurity 7, 2,6-Dimethylphenol, Phenol, 2,6-dimethyl-, Vic-m-xylenol, Xylenol 235, FEMA No. 3249, NSC 2123, Dimethylphenol, 2,6-, Xylenol 2,6-dimethylphenol
- Cat. No.
- P-M117-006
- CAS
- 576-26-1
- Alternative CAS
- N/A
- Formula
- C8H10O
- Molecular weight
- 122.17 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Mexiletine
A class IB antiarrhythmic that blocks sodium channels in the heart, a relative of lidocaine that works by mouth: on the market since 1975, it is used for ventricular arrhythmias.
Did you know?It also acts on sodium channels in muscles: this is why in 2018 it was approved in Europe as an orphan medicine for non-dystrophic myotonia, in which muscles struggle to relax after contracting.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Mexiletine impurity A CRSEP Y0002176
More products in the Mexiletine family
Active ingredientMexiletineCat. No. P-M117-001CAS 31828-71-4
Active ingredientMexiletine HClCat. No. P-M117-002CAS 5370-01-4
Pharmacopoeial impurityMexiletine EP Impurity CCat. No. P-M117-003CAS 2059988-38-2
Pharmacopoeial impurityMexiletine EP Impurity C DiHClCat. No. P-M117-004CAS 2059988-39-3
Pharmacopoeial impurityMexiletine EP Impurity DCat. No. P-M117-005CAS 26583-71-1
Pharmacopoeial impurityMexiletine Hydrochloride EP Impurity BCat. No. P-M117-007CAS 53012-41-2
Pharmacopoeial impurityMexiletine Hydrochloride EP Impurity DCat. No. P-M117-008CAS 2724689-76-1
Isotopically labelledMexiletine-d3 HClCat. No. P-M117-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.