Active ingredientCrotamitonCat. No. P-C258-001CAS 483-63-6
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Impurity or related compound · Crotamiton family
Pharmaceutical analytical standardN-(2-Methylphenyl)but-2-enamide
Synonyms: N-(2-Methylphenyl)-2-butenamide, Crotamiton Impurity 35
- Cat. No.
- P-C258-008
- CAS
- 96686-24-7
- Alternative CAS
- N/A
- Formula
- C11H13NO
- Molecular weight
- 175.23 g/mol
- Category
- Impurity or related compound
Family: Crotamiton
A topical medicine against scabies and against itching of various origins, such as insect bites: it was patented in the late 1940s in Switzerland and is still used today as a cream or lotion.
Did you know?For decades its anti-itch effect remained unclear: a 2017 study suggests that it blocks TRPV4, an ion channel in sensory nerve fibres.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Crotamiton family
Active ingredientCrotamitonCat. No. P-C258-001CAS 483-63-6
Pharmacopoeial impurityCrotamiton EP Impurity ACat. No. P-C258-002CAS 13936-71-5
Pharmacopoeial impurityCrotamiton EP Impurity BCat. No. P-C258-003CAS 1195353-67-3
Pharmacopoeial impurityCrotamiton EP Impurity DCat. No. P-C258-004CAS 13936-60-2
Impurity(E)-CrotamitonCat. No. P-C258-005CAS 124236-29-9
Impurity(Z)-CrotamitonCat. No. P-C258-006CAS 124236-30-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.