Active ingredientDovitinibCat. No. P-D178-001CAS 405169-16-6
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Impurity or related compound · Dovitinib family
Pharmaceutical analytical standardN-Desmethyl Dovitinib
Synonyms: Desmethyldovitinib
- Cat. No.
- P-D178-004
- CAS
- 668432-44-8
- Alternative CAS
- N/A
- Formula
- C20H19FN6O
- Molecular weight
- 378.41 g/mol
- Category
- Impurity or related compound
Family: Dovitinib
An investigational oral inhibitor of many receptor tyrosine kinases at once, including FGFR 1, 2 and 3, VEGFR and PDGFR: it was studied in several tumours, from breast to kidney, reaching phase 3 in metastatic renal cell carcinoma in 2011, without being approved.
Did you know?Chemically it is a benzimidazole-quinolinone: it contains the benzimidazole ring, one of the most widely used in medicines and found in nature in vitamin B12, where it helps hold the cobalt atom.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Dovitinib family
Active ingredientDovitinibCat. No. P-D178-001CAS 405169-16-6
Isotopically labelledDovitinib-d8Cat. No. P-D178-002
Isotopically labelledN-Desmethyl Dovitinib-d8Cat. No. P-D178-003CAS 1246814-93-6Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.