Active ingredientSiponimodCat. No. P-S047-001CAS 1230487-00-9
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Nitrosamine · Siponimod family
Pharmaceutical analytical standardN-Nitroso Siponimod Impurity 2
Synonyms: 2-[[[4-[(E)-N-[[4-Cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-C-methylcarbonimidoyl]-2-ethylphenyl]methyl-nitrosoamino]methyl]prop-2-enoic acid
- Cat. No.
- P-S047-007
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C29H34F3N3O4
- Molecular weight
- 545.60 g/mol
- Category
- Nitrosamine
Family: Siponimod
A selective modulator of the sphingosine-1-phosphate receptors S1P1 and S1P5: it keeps lymphocytes in the lymph nodes, stopping them from reaching the nervous system. Approved in 2019 in the United States and then in Europe for active secondary progressive multiple sclerosis.
Did you know?Before starting it, a genetic test of the CYP2C9 gene, the enzyme that breaks it down, is required: it is one of the medicines where the patient's genetic profile guides treatment.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Siponimod family
Active ingredientSiponimodCat. No. P-S047-001CAS 1230487-00-9
Active ingredientSiponimod TrifluoroacetateCat. No. P-S047-002
MetaboliteSiponimod M3 MetaboliteCat. No. P-S047-003
Isotopically labelledSiponimod-d11Cat. No. P-S047-004
Isotopically labelledSiponimod-d5Cat. No. P-S047-005
NitrosamineN-Nitroso Siponimod Impurity 1Cat. No. P-S047-006
Impurity(Z)-SiponimodCat. No. P-S047-008
ImpuritySiponimod Impurity 1Cat. No. P-S047-009CAS 2474774-17-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.