Active ingredientSotorasibCat. No. P-S070-001CAS 2252403-56-6
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Nitrosamine · Sotorasib family
Pharmaceutical analytical standardN-Nitroso Sotorasib Impurity 3
- Cat. No.
- P-S070-008
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C8H13N3O2
- Molecular weight
- 183.21 g/mol
- Category
- Nitrosamine
Family: Sotorasib
An anticancer drug that blocks the KRAS protein carrying the G12C mutation, approved in the United States in May 2021 and in the European Union in January 2022 for non-small cell lung cancer.
Did you know?It was the first targeted therapy approved for tumours with any KRAS mutation: it locks irreversibly onto the sulphur atom of the cysteine found in the mutated protein.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Sotorasib family
Active ingredientSotorasibCat. No. P-S070-001CAS 2252403-56-6
MetaboliteSotorasib Metabolite 1Cat. No. P-S070-003
Isotopically labelledSotorasib-d3Cat. No. P-S070-004
Isotopically labelledSotorasib-d7Cat. No. P-S070-005
NitrosamineN-Nitroso Sotorasib Impurity 1Cat. No. P-S070-006
NitrosamineN-Nitroso Sotorasib Impurity 2Cat. No. P-S070-007
ImpuritySotorasib Impurity 1Cat. No. P-S070-009CAS 1604376-50-2
ImpuritySotorasib Impurity 2Cat. No. P-S070-010CAS 2484718-65-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.