Active ingredientNabumetoneCat. No. P-N001-001CAS 42924-53-8
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Pharmacopoeial impurity · Nabumetone family
Pharmaceutical analytical standardNabumetone EP Impurity F
Synonyms: 6,6'-dimethoxy-2,2'-binaphthalene, 6,6'-Dimethoxy-2,2'-binaphthalenyl, 2-methoxy-6-(6-methoxynaphthalen-2-yl)naphthalene, NSC 408779, Nabumetone impurity f (ep impurity), Nabumetone impurity, 6,6-dimethoxy-2,2'-binaphthyl-, Nabumetone impurity, 6,6-dimethoxy-2,2'-binaphthyl-(usp impurity), Nabumetone specified impurity F
- Cat. No.
- P-N001-006
- CAS
- 29619-45-2
- Alternative CAS
- N/A
- Formula
- C22H18O2
- Molecular weight
- 314.38 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Nabumetone
A naphthalene-derived non-steroidal anti-inflammatory drug, used to relieve pain and inflammation in osteoarthritis and rheumatoid arthritis; it was approved in the United States in 1991.
Did you know?Unlike most anti-inflammatories it is not an acid: it is an almost inactive prodrug that the liver converts into the real active substance, 6-MNA.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Nabumetone impurity F CRSEP N0020030
More products in the Nabumetone family
Active ingredientNabumetoneCat. No. P-N001-001CAS 42924-53-8
Pharmacopoeial impurityNabumetone EP Impurity ACat. No. P-N001-002CAS 343272-52-6
Pharmacopoeial impurityNabumetone EP Impurity BCat. No. P-N001-003CAS 343272-51-5
Pharmacopoeial impurityNabumetone EP Impurity CCat. No. P-N001-004CAS 65726-24-1
Pharmacopoeial impurityNabumetone EP Impurity ECat. No. P-N001-005CAS 343272-53-7
Pharmacopoeial impurityNabumetone USP Related Compound ACat. No. P-N001-007CAS 127053-22-9
Isotopically labelledNabumetone-d3Cat. No. P-N001-008CAS 1216770-08-9
ImpurityNabumetone Impurity 1Cat. No. P-N001-009CAS 56600-90-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.