Active ingredientNaloxone HydrochlorideCat. No. P-N017-001CAS 357-08-4
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Pharmacopoeial impurity · Naloxone family
Pharmaceutical analytical standardNaloxone EP Impurity A Hydrochloride
Synonyms: Noroxymorphone Hydrochloride, Noroxymorphone.HCl, Naloxone EP Impurity A HCl
- Cat. No.
- P-N017-004
- CAS
- 52446-24-9
- Alternative CAS
- 33522-95-1 (free base)
- Formula
- C16H17NO4·HCl
- Molecular weight
- 323.77 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Naloxone
An opioid antagonist developed and patented in 1961 by Jack Fishman and Mozes Lewenstein, approved in the United States in 1971: it is used to rapidly reverse the effects of opioids, especially respiratory depression.
Did you know?It also became a research tool: in 1978 a study on pain after dental surgery showed that naloxone reduced the placebo effect, a sign that placebo works partly through endorphins.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Naloxone family
Active ingredientNaloxone HydrochlorideCat. No. P-N017-001CAS 357-08-4
Active ingredientNaloxone Hydrochloride DihydrateCat. No. P-N017-002CAS 51481-60-8
Pharmacopoeial impurityNaloxone EP Impurity ACat. No. P-N017-003CAS 33522-95-1
MetaboliteNaloxone EP Impurity A-D-GlucuronideCat. No. P-N017-005CAS 76636-08-3
Pharmacopoeial impurityNaloxone EP Impurity BCat. No. P-N017-006CAS 1352085-46-1
Pharmacopoeial impurityNaloxone EP Impurity CCat. No. P-N017-007CAS 2139253-68-0
Pharmacopoeial impurityNaloxone EP Impurity DCat. No. P-N017-008CAS 26451-92-3
Pharmacopoeial impurityNaloxone EP Impurity ECat. No. P-N017-009CAS 211738-08-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.