Active ingredientNebivolol HydrochlorideCat. No. P-N026-001CAS 152520-56-4
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Impurity or related compound · Nebivolol family
Pharmaceutical analytical standardNebivolol Impurity 31
Synonyms: (1S)-2-(Benzylamino)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol
- Cat. No.
- P-N026-063
- CAS
- 129050-29-9
- Alternative CAS
- N/A
- Formula
- C18H20FNO2
- Molecular weight
- 301.36 g/mol
- Category
- Impurity or related compound
Family: Nebivolol
A third-generation beta-blocker, highly selective for the heart's beta-1 receptors and able to widen blood vessels through nitric oxide. Patented in 1983 and in use since 1997, it is used for hypertension and heart failure.
Did you know?It is a mix of two enantiomers with different jobs: the d form blocks beta-1 receptors, while the l form triggers the release of nitric oxide, which relaxes the vessels.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Nebivolol family
Active ingredientNebivolol HydrochlorideCat. No. P-N026-001CAS 152520-56-4
Active ingredientD-Nebivolol HydrochlorideCat. No. P-N026-002CAS 213132-06-0
Pharmacopoeial impurityNebivolol EP Impurity BCat. No. P-N026-003CAS 119365-23-0
Pharmacopoeial impurityNebivolol EP Impurity ACat. No. P-N026-005CAS 1416402-13-5
Pharmacopoeial impurityNebivolol EP Impurity C HCl SaltCat. No. P-N026-006
Pharmacopoeial impurityNebivolol EP Impurity DCat. No. P-N026-007CAS 119365-22-9
Pharmacopoeial impurityNebivolol USP Related Compound A HClCat. No. P-N026-008
Pharmacopoeial impurityNebivolol USP Related Compound CCat. No. P-N026-009CAS 876514-31-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.