Active ingredientNetarsudilCat. No. P-N039-001CAS 1254032-66-0
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Impurity or related compound · Netarsudil family
Pharmaceutical analytical standardNetarsudil Impurity 10
Synonyms: [4-[(2R)-1-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate
- Cat. No.
- P-N039-018
- CAS
- 2250308-75-7
- Alternative CAS
- N/A
- Formula
- C34H38N2O7
- Molecular weight
- 586.69 g/mol
- Category
- Impurity or related compound
Family: Netarsudil
A Rho kinase (ROCK) inhibitor eye drop that lowers the pressure inside the eye in open-angle glaucoma or ocular hypertension; approved in the United States in 2017 and in Europe in 2019.
Did you know?It acts directly on the trabecular meshwork, the main drainage route for the aqueous humour, easing its outflow; it also blocks the noradrenaline transporter, a second mechanism of action.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Netarsudil family
Active ingredientNetarsudilCat. No. P-N039-001CAS 1254032-66-0
Isotopically labelledNetarsudil-d4Cat. No. P-N039-002CAS 2377406-71-6
Impurity(R)-Netarsudil DimesylateCat. No. P-N039-003
Impurity2,4-Dimethylbenzoic acidCat. No. P-N039-004CAS 611-01-8
ImpurityNetarsudil Impurity 1Cat. No. P-N039-005CAS 2097334-16-0
Impurity6-AminoisoquinolineCat. No. P-N039-006CAS 23687-26-5
Impurityent-Netarsudil Impurity 2 HydrochlorideCat. No. P-N039-007CAS 2565792-57-4
ImpurityNetarsudil Amino Acid ImpurityCat. No. P-N039-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.