Active ingredientNicardipine HClCat. No. P-N045-001CAS 54527-84-3
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Pharmacopoeial impurity · Nicardipine family
Pharmaceutical analytical standardNicardipine USP Related Compound A
Synonyms: Carboxy-nifedipine, Lercanidipine Impurity 9, Methyl hydrogen 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, Monomethyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
- Cat. No.
- P-N045-037
- CAS
- 74936-72-4
- Alternative CAS
- N/A
- Formula
- C16H16N2O6
- Molecular weight
- 332.31 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Nicardipine
A dihydropyridine calcium channel blocker, patented in 1973 and in use since 1981: it widens the arteries and is used for hypertension and angina, including intravenously in hypertensive crises.
Did you know?Among the calcium channel blockers of its family it is especially selective for the blood vessels of the brain and heart, which is why it is also used after a subarachnoid haemorrhage.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Nicardipine family
Active ingredientNicardipine HClCat. No. P-N045-001CAS 54527-84-3
Pharmacopoeial impurityNicardipine EP Impurity A DihydrochlorideCat. No. P-N045-002CAS 2724726-76-3
Pharmacopoeial impurityNicardipine EP Impurity ACat. No. P-N045-003CAS 59875-58-0
Pharmacopoeial impurityNicardipine EP Impurity A HClCat. No. P-N045-004CAS 1216817-27-4
Pharmacopoeial impurityNicardipine EP Impurity B DiHClCat. No. P-N045-005CAS 71784-27-5
Pharmacopoeial impurityNicardipine EP Impurity CCat. No. P-N045-006CAS 21881-77-6
Impurity(R)-Nicardipine USP Related Compound ACat. No. P-N045-007CAS 76093-33-9
Impurity(S)-Nicardipine USP Related Compound ACat. No. P-N045-008CAS 76093-34-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.