Pharmacopoeial impurityNifedipine EP Impurity ACat. No. P-N055-002CAS 67035-22-7
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Active ingredient · Nifedipine family
Pharmaceutical analytical standardNifedipine
Synonyms: Procardia, Adalat, Procardia XL, Citilat, Oxcord, Adalat CC, Fenihidine, Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, Bay-a-1040, Coracten, Afeditab CR, Adipine XL, Afeditab, Calcilat, Nifedical, Nifensar XL, Nifedical XL, Adalate LP, NSC 757242, Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-3,5-pyridinedicarboxylate, Cordipine, Korinfar, Calanif, Kentipine, Nifelease, Vasad, Nifopress ret, Cardilate mr, Coracten sr, Neozipine xl, Nifopress mr, Nimodrel xl, Nivaten ret, Adalat ret, Coroday mr, Nife-wolff, Unipine xl, Adalat ic, Adanif xl, Nifedicalxl XL, Nifediac Cc, Valni xl, Angiopine 5, Fortipine la40, Angiopine 10, Angiopine 40 la, Angiopine mr 10, Angiopine mr 20, Kentipine mr 10, Kentipine mr 20, Tensipine mr 10, Tensipine mr 20, Adalat a.r., Genalat 10 ret, Genalat 20 ret, Hypolar ret 10, Hypolar ret 20, Nifedotard 20 mr, Nimodrel mr 10, Nimodrel mr 20, Adipine mr 10, Adipine mr 20, Calchan mr 10, Calchan mr 20, Hypolar xl 30, Nifedipress mr 10, Nifedipress mr 20, Slofedipine xl 30, Slofedipine xl 60, Adalat la 20, Adalat la 30, Adalat la 60, Cordipin, Corinfar, Fenihidin, Sepamit, Chronadalate, Corynphar, Duranifin, Hexadilat, Introcar, Kordafen, Tibricol, Adalate, Adapine, Pidilat, Zenusin, Orix, Adalat LA, Dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate, Nifangin, Nifecard, Nifediac, Nifedin, Nifelat, Alonix S, Adalat CR, Dignokonstant, Adapress, Aldipin, Alfadal, Angipec, Aprical, Bonacid, Calcibloc, Calcigard, Cardilat, Cardionorm, Cordafen, Cordaflex, Cordalat, Cordicant, Cordilan, Corotrend, Dilafed, Dipinkor, Ecodipi, Ecodipin, Fenamon, Hadipin, Macorel, Megalat, Myogard, Nifecor, Nifedicor, Nifedipres, Nifelan, Nificard, Alonix, Anifed, Anpine, Camont, Fedcor, Glopir, Depin, Alat, Adalat Retard, Fedcor Retard, Adalat Crono, Adalat Oros, Ecodipin E, Apo-Nifed, Fenamon SR, Adalat FT, Adalat LP, Adalat PA, Adalat GITS, Adalat GITS 30, Emaberin, Dilcor, Aprical long, Slofedipine XL, Fortipine LA, Tensipine MR, Adalat XL, Dimethyl 4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, Tensipine
- Cat. No.
- P-N055-001
- CAS
- 21829-25-4
- Alternative CAS
- 193689-82-6 (alternative CAS, same compound)
- 101539-70-2 (alternative CAS, same compound)
- 915092-63-6 (alternative CAS, same compound)
- Formula
- C17H18N2O6
- Molecular weight
- 346.34 g/mol
- Category
- Active ingredient (API)
A dihydropyridine calcium channel blocker that widens blood vessels, developed in Germany, patented in 1967 and approved in the United States in 1981; it is used for high blood pressure and angina.
Did you know?It is very sensitive to light: in daylight it readily turns into a nitrosophenylpyridine derivative, so in the laboratory it is analysed in the dark or under golden light.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- NifedipineBP 462
- Nifedipine CRSEP N0750000
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Pharmacopoeial impurityNifedipine EP Impurity C (as E/Z-Mixture)Cat. No. P-N055-004CAS 39562-27-1
Pharmacopoeial impurityNifedipine EP Impurity D (Z)Cat. No. P-N055-005CAS 14205-39-1
Pharmacopoeial impurityNifedipine EP Impurity D (E)Cat. No. P-N055-006CAS 80012-11-9
MetaboliteNifedipine MetaboliteCat. No. P-N055-007CAS 34783-31-8
MetaboliteNifedipine Metabolite lactoneCat. No. P-N055-008
Isotopically labelledNifedipine EP Impurity A-d6Cat. No. P-N055-009CAS 125464-52-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.