Active ingredientNirmatrelvirCat. No. P-N071-001CAS 2628280-40-8
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Impurity or related compound · Nirmatrelvir family
Pharmaceutical analytical standardNirmatrelvir Impurity 14
Synonyms: (1R,2S,5S)-3-[(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid
- Cat. No.
- P-N071-050
- CAS
- 2755812-45-2
- Alternative CAS
- N/A
- Formula
- C16H23F3N2O4
- Molecular weight
- 364.36 g/mol
- Category
- Impurity or related compound
Family: Nirmatrelvir
An antiviral that blocks the main protease (Mpro) of SARS-CoV-2, the enzyme the virus uses to cut its own proteins and multiply; it is taken together with ritonavir and was authorised in the United States in December 2021 against COVID-19.
Did you know?Its partner, ritonavir, born as an HIV medicine, does not act on the coronavirus: it blocks the CYP3A enzyme that would break nirmatrelvir down, so raising its levels in the blood.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Nirmatrelvir family
Active ingredientNirmatrelvirCat. No. P-N071-001CAS 2628280-40-8
MetaboliteNirmatrelvir Metabolite 1Cat. No. P-N071-002CAS 2755812-08-7
MetaboliteNirmatrelvir Metabolite 2Cat. No. P-N071-003CAS 2755812-09-8
MetaboliteNirmatrelvir Metabolite 3Cat. No. P-N071-004CAS 2755812-10-1
MetaboliteNirmatrelvir Metabolite 4Cat. No. P-N071-005CAS 2755812-07-6
Isotopically labelledNirmatrelvir-d9Cat. No. P-N071-006CAS 2861202-76-6
ImpurityNirmatrelvir Impurity 1Cat. No. P-N071-007CAS 34306-42-8
ImpurityNirmatrelvir Impurity 2Cat. No. P-N071-008CAS 741267-75-4Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.