Pharmacopoeial impurityNisoldipine USP Related Compound DCat. No. P-N073-002CAS 103026-83-1
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Active ingredient · Nisoldipine family
Pharmaceutical analytical standardNisoldipine
Synonyms: Sular, Nisocor, Baymycard, Bay k 5552, Geomatrix 16e, NSC 759106, Syscor mr 10, Syscor mr 20, Syscor mr 30, Zadipina, Syscor, Isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridincarboxylat, Pharmakon1600-01505390, Isobutyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate, Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Cat. No.
- P-N073-001
- CAS
- 63675-72-9
- Alternative CAS
- N/A
- Formula
- C20H24N2O6
- Molecular weight
- 388.42 g/mol
- Category
- Active ingredient (API)
A calcium channel blocker of the dihydropyridine family, patented in 1975 and approved for medical use in 1990: it is used for hypertension and chronic angina pectoris.
Did you know?Only about 4-8% of an oral dose reaches the blood, and grapefruit juice raises its levels because it blocks CYP3A4, the enzyme that breaks it down.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Nisoldipine family
Pharmacopoeial impurityNisoldipine USP Related Compound DCat. No. P-N073-002CAS 103026-83-1
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Isotopically labelledNisoldipine-d6Cat. No. P-N073-005CAS 1285910-03-3
ImpurityDehydronitrosonisoldipineCat. No. P-N073-006CAS 87375-91-5
NitrosamineN-Nitroso NisoldipineCat. No. P-N073-007
Impurity4-Hydroxy NisoldipineCat. No. P-N073-008CAS 106685-70-5
ImpurityNisoldipine Impurity BCat. No. P-N073-009CAS 61312-59-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.