Active ingredientNelarabineCat. No. P-N029-001CAS 121032-29-9
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Impurity or related compound · Nelarabine family
Pharmaceutical analytical standardO-(6)-Methylguanine
Synonyms: Nelarabine Impurity 11, 6-Methoxy-9H-Purin-2-Amine, 6-methoxy-7H-purin-2-amine, Purine, 2-amino-6-methoxy-, NSC 37364, Methylguanine, o(6)-, Nelarabine metabolite (methylguanine), O-Methylguanine, Methylguanine
- Cat. No.
- P-N029-010
- CAS
- 20535-83-5
- Alternative CAS
- N/A
- Formula
- C6H7N5O
- Molecular weight
- 165.16 g/mol
- Category
- Impurity or related compound
Family: Nelarabine
A purine nucleoside analogue chemotherapy drug, approved in the United States in 2005 for T-cell acute lymphoblastic leukaemia and T-cell lymphoblastic lymphoma that are refractory or have relapsed after at least two chemotherapy regimens.
Did you know?It is a water-soluble version of ara-G carrying an extra methoxy group: in the body the enzyme adenosine deaminase removes it, releasing the active drug, to which T lymphocytes are particularly sensitive.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Nelarabine family
Active ingredientNelarabineCat. No. P-N029-001CAS 121032-29-9
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ImpurityNelarabine Impurity 2Cat. No. P-N029-004CAS 1233127-29-1
ImpurityNelarabine Impurity 3Cat. No. P-N029-005CAS 7013-16-3
Impurity9-beta-D-ArabinofuranosylguanineCat. No. P-N029-006CAS 38819-10-2
ImpurityAra-DAPCat. No. P-N029-007CAS 34079-68-0
ImpurityNelarabine Impurity 4Cat. No. P-N029-008CAS 1173825-84-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.