Active ingredientOxymetazolineCat. No. P-O073-001CAS 1491-59-4
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Active ingredient · Oxymetazoline family
Pharmaceutical analytical standardOxymetazoline Hydrochloride
Synonyms: Ocuclear, Afrazine, Nostrilla, Rhofade, Visine L.R., Vicks Sinex, Anefrin nasal, UPNEEQ, Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, monohydrochloride, Sinufrin, Breaze, Major, Afrin Original, Meijer Original, Severe Anefrin, Allergy Sinus, Breaze Nasal, Equate Nasal, Family Dollar, Leader Nasal, Severe Nasal, Sinufrin Plus, Sunmark Nasal, Topcare Nasal, Sinufrin Neilmed, Circle K, Congestion Relief, Ultra Fine Mist, Care One Nasal, DG Health Nasal, Kroger No Drip, Nasal Mist Cvs, Afrin No Drip, Good Sense Nasal, No Drip Original, Sound Body Nasal, Tukol Max Action, No Drip, CVS Health Sinus, Health Mart Nasal, Oxymethazoline HCL, Topcare sinus nasal, No Drip Nasal Mist, Afrin Original Nasal, Assured Nasal Relief, Giltuss Severe Sinus, Nasal Mist Walgreens, Nasalub Nasal Relief, Quality Choice Nasal, Afrin No Drip Night, CVS Health No Drip, Equate Nasal Original, Exchange Select Nasal, Leader Original Nasal, Maximum Strenth Nasal, Shopko Original Nasal, Sinufrin Plus Neilmed, Propolis nasal, Anefrin Nasal Original, Plus nasal, Sunmark Nasal Original, Nasal Relief Rite Aid, No Drip Premier Value, Afrin Severe Congestion, DG health sinus severe, Publix Maximum Strength, Signature Care Original, Original No Drip Nasal, Care One Nasal Original, Major Nasal Decongestant, Xlear Nasal Decongestant, no more nosebleed, Basic care no drip nasal, BEST CHOICE No Drip, Afrin Original Pump Mist, Breaze Nasal Moisturizing, CVS Health Sinus Relief, CVS Original Nasal Mist, Dg Health Nasal Original, Family Care Nasal Relief, Mucinex Nasal Full Force, Publix Extra Moisturizing, Severe Sinus Relief Mist, Afrin Allergy Sinus Nasal, Best Choice Allergy Sinus, No Drip Severe Congestion, Propolis nasal plus, Circle K Congestion Relief, Nasal Decongestant Original, Winco Foods Original Nasal, Zicam Intense Sinus Relief, No Drip Severe Nasal Mist, Vicks Sinex Severe Original, Afrin No-Drip Allergy Sinus, Best Choice Maximum Strength, Best Choice Ultra Fine Mist, CVS Health Ultra Fine Mist, Good Neighbor Pharmacy Nasal, No Drip Nasal Mist Original, Assured Nasal Relief Original, Extra Moisturizing Nasal Mist, No Drip Severe Anefrin Nasal, Quality Choice Nasal Original, Rexall Sinus Nasal Pump Mist, Ultra Fine Mist Sinus Relief, ORIGINAL Nasal PUMP MIST, Afrin No Drip Night Chamomile, Leader Severe Congestion Nasal, Marc Glassman Maximum Strength, Shopko Severe Congestion Nasal, Leader Extra Moisturizing Nasal, MUCINEX Childrens Stuffy Nose, Quality Choice Maximum Strength, Shopko Extra Moisturizing Nasal, Zicam Extreme Congestion Relief, CareOne Severe Congestion Nasal, Severe Congestion Nasal no drip, Afrin No Drip Severe Congestion, Discount Drug Mart Severe Nasal, Nasal Decongestant Premier Value, Afrin No Drip Extra Moisturizing, Afrin NoDrip Allergy Sinus Night, Extra Moisturizing No Drip Nasal, Original No Drip Nasal Walgreens, Signature Care Nasal Decongestant, Todays Health Sinus Nasal Relief, Afrin No Drip Original Pump Mist, Discount Drug Mart Original Nasal, Good Neighbor No Drip Nasal Mist, AVON HeXashield Congestion Relief, Extra Moisturizing Nasal Pump Mist, SUDAFED OM Sinus Severe Original, CVS Severe Nasal Congestion Relief, Todays Health Nasal Relief Original, TOPCARE No Drip Extra Moisturizing, Nasal Decongestant Extra Moisturizing, Afrin No Drip Pump Mist Bundle Pack, Discount drug mart Extra Moisturizing, ORIGINAL Nasal PUMP MIST No Drip, Quality Choice Nasal Maximum Strength, Assured Severe Congestion Nasal Relief, Max Str.Nasal Relief Severe Congestion, No Drip Severe Congestion Premier Value, Congestion Relief Lil Drug Store Products, Discount Drug Mart Maximum Strength Nasal, Severe Congestion Nasal no drip Walgreens, AVON HeXashield Congestion Relief Original, Discount Drug Mart Severe Congestion Nasal, Extra Moisturizing No Drip Nasal Walgreens, Winco Foods Severe Congestion Nasal Relief, Winco Foods Extra Moisturizing Nasal Relief, KROGER No Drip Nasal Mist Severe Congestion, Extra Moisturizing Nasal Pump Mist Anti Drip, Rhinase D Gel Moisturizing Nasal Decongestant, Todays Health Nasal Relief Extra Moisturizing, HEB Nasal decongestant No Drip Extra Moisturizing, Good Neighbor No Drip Nasal Mist Extra Moisturizing, Nasal Decongestant Extra Moisturizing Premier Value, Severe Congestion Nasal Anti-Drip Nasal Decongestant, Vicks Sinex SEVERE MOISTURIZING ULTRA FINE MIST, Children Afrin Extra Moisturizing Stuffy Nose Pump Mist, No Drip Nasal Mist Nasal Decongestant Severe Congestion, Children Afrin No Drip Extra Moisturizing Stuffy Nose Pump Mist, Children Afrin Extra Moisturizing Stuffy Nose Pump Mist Stuffy Nose Pump Mist, Children Afrin No Drip Extra Moisturizing Stuffy Nose Pump Mist Stuffy Nose Pump Mist, Afrin hydrochloride, Lliadine, Nasivin, Nasivine, Neonabel, Nafrine hydrochloride, LLiadin Mini Paediatric, Sinex, Dristan Long Lasting Nasal Mist, Sudafed OM, Rhfade, Oximetazoline hydrochloride, Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, hydrochloride
- Cat. No.
- P-O073-002
- CAS
- 2315-02-8
- Alternative CAS
- 1491-59-4 (free base)
- 1629237-42-8 (hydrobromide)
- 1629237-45-1 (sulfate)
- Formula
- C16H24N2O·HCl
- Molecular weight
- 296.84 g/mol
- Category
- Active ingredient (API)
Family: Oxymetazoline
A nasal decongestant of the imidazoline family that narrows blood vessels by stimulating alpha-adrenergic receptors; it was developed in Germany in 1961 by Wolfgang Fruhstorfer and Helmut Müller-Calgan.
Did you know?The same ingredient that clears a blocked nose has been approved in the United States as a cream for rosacea redness (2017) and as eye drops to lift a drooping eyelid (2020).
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Oxymetazoline hydrochloride CRSEP O0290000
More products in the Oxymetazoline family
Active ingredientOxymetazolineCat. No. P-O073-001CAS 1491-59-4
Pharmacopoeial impurityOxymetazoline EP Impurity A HydrochlorideCat. No. P-O073-003CAS 1391053-50-1
Pharmacopoeial impurityOxymetazoline EP Impurity ACat. No. P-O073-004CAS 1391194-44-7
Pharmacopoeial impurityOxymetazoline EP Impurity B HClCat. No. P-O073-005CAS 1218-35-5
Pharmacopoeial impurityOxymetazoline EP Impurity CCat. No. P-O073-006CAS 55699-13-3
Pharmacopoeial impurityOxymetazoline EP Impurity DCat. No. P-O073-007CAS 55699-12-2
Pharmacopoeial impurityOxymetazoline EP Impurity ECat. No. P-O073-008CAS 55699-10-0
MetaboliteOxymetazoline O GlucuronideCat. No. P-O073-009CAS 1267481-12-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.