Active ingredientPitolisant HydrochlorideCat. No. P-P141-001CAS 903576-44-3
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Impurity or related compound · Pitolisant family
Pharmaceutical analytical standardp-Chloro Oxopitolisant
Synonyms: Pitolisant impurity 6, 1-(4-chlorophenyl)-3-(3-piperidin-1-ylpropoxy)propan-1-one
- Cat. No.
- P-P141-004
- CAS
- 2858590-15-3
- Alternative CAS
- N/A
- Formula
- C17H24ClNO2
- Molecular weight
- 309.83 g/mol
- Category
- Impurity or related compound
Family: Pitolisant
An antagonist and inverse agonist of the histamine H3 receptor, approved in the European Union in 2016 for narcolepsy: it increases histamine release in the brain, promoting wakefulness.
Did you know?The H3 receptor was discovered in 1983 by the Frenchman Jean-Charles Schwartz with his colleagues Arrang and Garbarg; decades later Schwartz himself developed pitolisant.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Pitolisant family
Active ingredientPitolisant HydrochlorideCat. No. P-P141-001CAS 903576-44-3
Isotopically labelledPitolisant-d6 HClCat. No. P-P141-002CAS 2416991-78-9
ImpurityPitolisant Impurity 1Cat. No. P-P141-003CAS 110129-10-7
ImpurityPitolisant Butyl AnalogCat. No. P-P141-005CAS 875229-73-5
ImpurityPitolisant Deschloro ImpurityCat. No. P-P141-006CAS 362665-54-1
ImpurityPitolisant Despiperidine ImpurityCat. No. P-P141-007CAS 6282-88-8
ImpurityPitolisant Impurity 2Cat. No. P-P141-008
ImpurityPitolisant Impurity 3Cat. No. P-P141-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.