Pharmacopoeial impurityPaclitaxel EP Impurity ACat. No. P-P001-002CAS 173101-54-7
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Active ingredient · Paclitaxel family
Pharmaceutical analytical standardPaclitaxel
Synonyms: TAXOL, Yewtaxan, Taxol A, Genaxol, Plaxicel, Ebetaxel, Genetaxyl, Capxol, Paxene, OncoGel, Genexol, Intaxel, Mitotax, Pacliex, Onxol, TaxAlbin, Cyclopax, Paxceed, Onxal, Zisu, EmPAC, Padexol, Taxus, EndoTAG 1, LEP-ETU, NSC 125973, Nanoxel, Paclitaxol, Sindaxel, Infinnium, Pacitaxel, Abraxane, LipoPac, Genexol-PM, Cynviloq, Xorane, Anzatax, Nanotaxel, Paclical, Pacligel, Paxoral, Praxel, Apealea, Apexelsin, Naveruclif, Pazenir, p-ssmm-vip, NSC 745099
- Cat. No.
- P-P001-001
- CAS
- 33069-62-4
- Alternative CAS
- 181140-35-2 (hydrate)
- 197778-55-5 (hydrate)
- 1203669-79-7 (alternative CAS, same compound)
- Formula
- C47H51NO14
- Molecular weight
- 853.92 g/mol
- Category
- Active ingredient (API)
Discovered in the 1960s in the bark of the Pacific yew (Taxus brevifolia) by Monroe Wall and Mansukh Wani, who published its structure in 1971. Approved as a cancer medicine in 1992, it is now made by semi-synthesis from the needles of the European yew or by plant cell culture.
Did you know?The yew is one of the most poisonous trees in our woods: almost every part of it is toxic. Yet it gave us one of the cancer medicines that have saved the most lives.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Paclitaxel CRSEP Y0000698
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Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.