Active ingredientPalbociclibCat. No. P-P004-001CAS 571190-30-2
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Impurity or related compound · Palbociclib family
Pharmaceutical analytical standardPalbociclib Impurity 22
Synonyms: 8-Cyclopentyl-6-ethenyl-5-methyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrido[2,3-d]pyrimidin-7-one, Desoxo-palbociclib, Pyrido(2,3-d)pyrimidin-7(8H)-one, 8-cyclopentyl-6-ethenyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)-
- Cat. No.
- P-P004-059
- CAS
- 2204863-06-7
- Alternative CAS
- N/A
- Formula
- C24H29N7O
- Molecular weight
- 431.54 g/mol
- Category
- Impurity or related compound
Family: Palbociclib
The first CDK4/6 inhibitor approved, in 2015, for hormone receptor-positive breast cancer. It blocks the cycle by which tumour cells divide.
Did you know?The molecule had already been synthesised in the early 2000s and sat on the shelf for years, before new studies revealed its potential.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Palbociclib family
Active ingredientPalbociclibCat. No. P-P004-001CAS 571190-30-2
MetabolitePalbociclib N-GlucuronideCat. No. P-P004-002
Isotopically labelledPalbociclib-d8Cat. No. P-P004-003CAS 1628752-83-9
NitrosamineN-Nitroso Palbociclib Impurity 1Cat. No. P-P004-004CAS 2089333-12-8
NitrosamineN-Nitroso Palbociclib HClCat. No. P-P004-005
NitrosamineN-Nitroso Palbociclib Impurity 2Cat. No. P-P004-006
NitrosamineN-Nitroso Palbociclib Impurity 3Cat. No. P-P004-007
NitrosamineN-Nitroso Palbociclib Impurity 4Cat. No. P-P004-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.