ImpurityPemigatinib Impurity 1Cat. No. P-P036-002
Drag to rotate
Active ingredient · Pemigatinib family
Pharmaceutical analytical standardPemigatinib
Synonyms: Pemazyre
- Cat. No.
- P-P036-001
- CAS
- 1513857-77-6
- Alternative CAS
- N/A
- Formula
- C24H27F2N5O4
- Molecular weight
- 487.51 g/mol
- Category
- Active ingredient (API)
An inhibitor of fibroblast growth factor receptors (FGFR), approved in the United States in 2020 and in the European Union in 2021 for advanced cholangiocarcinoma with an FGFR2 fusion; since 2022 it has also been indicated for some myeloid/lymphoid neoplasms with FGFR1 rearrangement.
Did you know?It was the first targeted treatment approved in the United States for cholangiocarcinoma, cancer of the bile ducts, together with a genetic test that identifies patients with the FGFR2 fusion.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Pemigatinib family
ImpurityPemigatinib Impurity 1Cat. No. P-P036-002
ImpurityPemigatinib Impurity 2Cat. No. P-P036-003
ImpurityPemigatinib N-OxideCat. No. P-P036-004Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.