Pharmacopoeial impurityPhenobarbital EP Impurity BCat. No. P-P079-002CAS 58042-96-9
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Active ingredient · Phenobarbital family
Pharmaceutical analytical standardPhenobarbital
Synonyms: Phenobarbitone, 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione, Phenobarbitonum, Luminal, Phenobarbitol, Fenobarbital, Nunol, Phenylethylbarbiturate, Dormiral, Gardenal, Gardepanyl, Neurobarb, Phenobarbituric acid, Adonal, Agrypnal, Barbenyl, Barbiphenyl, Barbipil, Barbivis, Cratecil, Eskabarb, Liquital, Lubergal, Phenaemal, Phenonyl, Phenyral, Solfoton, Etilfen, Euneryl, Noptil, Somonal, Phenylethylmalonylurea, Phenylethylbarbituric acid, Amylofene, Aphenylbarbit, Aphenyletten, Barbophen, Bialminal, Calmetten, Codibarbita, Coronaletta, Dezibarbitur, Fenylettae, Glysoletten, Hennoletten, Hypnaletten, Hypnolone, Hypnoltol, Lepinaletten, Lumesettes, Lumofridetten, Pharmetten, Phenemalum, Phenobarbyl, Phenoluric, Phenolurio, Phenoturic, Phenyletten, Polcominal, Promptonal, Sedizorin, Sedonettes, Somnolens, Somnoletten, Spasepilin, Starilettae, Versomnal, Aephenal, Barbita, Barbonal, Bardorm, Cabronal, Calminal, Cardenal, Doscalun, Duneryl, Ensobarb, Ensodorm, Epidorm, Episedal, Epsylone, Fenbital, Fenemal, Fenosed, Haplopan, Hypnogen, Lepinal, Linasen, Lixophen, Lubrokal, Lumesyn, Luphenil, Luramin, Molinal, Nirvonal, Parkotal, Phenemal, Phenomet, Sedabar, Sedicat, Sedofen, Sedonal, Sedophen, Sevenal, Sombutol, Starifen, Talpheno, Teolaxin, Bartol, Epanal, Epilol, Haplos, Leonal, Lumen, Sedlyn, Seda-Tablinen, Blu-phen, Nova-Pheno, Hypno-Tablinetten, Phen-Bar, Stental Extentabs, Phenobarb, PHOB, Triabarb, Triphenatol, Tridezibarbitur, Lephebar, Lefebar, Zadonal, Austrominal, Thenobarbital, Tedral, Barbituric acid, 5-ethyl-5-phenyl-, NSC 9848, NSC 128143, Theominal, Pheno, Acid, Phenylethylbarbituric, Phenylbarbital, Phenobal, Hypnette, Somnosan, Chinoin, Henotal, Hysteps, Solu-Barb, Stental, Zadoletten, Barbinal, Barbiphen, Damoral, Dormina, Teoloxin, Theoloxin, Dormital, Barbilehae (barbilettae), Component of Tedral, Sedonal (sedative), Component of Slowten, Component of Antrocol, Component of Hecadrol, Component of Bronkotabs, Component of Primatene P, Component of Valpin 50-PB, Fenobarbitale, Chardonna-2, Barbinol, Fenemal recip, Phenobar, Tedrigen, Theophed, Mephobarbital M (nor)
- Cat. No.
- P-P079-001
- CAS
- 50-06-6
- Alternative CAS
- 17140-94-2 (magnesium salt)
- 57-30-7 (sodium salt)
- 54840-95-8 (sodium salt)
- 7645-06-9 (calcium salt)
- 7645-05-8 (alternative CAS, same compound)
- Formula
- C12H12N2O3
- Molecular weight
- 232.24 g/mol
- Category
- Active ingredient (API)
A barbiturate with sedative and antiepileptic action, first marketed in Germany in 1912: it is the oldest antiepileptic still in common use.
Did you know?Its effect against epilepsy was discovered almost by chance by the young German doctor Alfred Hauptmann, who gave it to his epileptic patients as a tranquilliser to help them sleep and saw their seizures decrease.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- PhenobarbitalBP 901
- Phenobarbital CRSEP P0900000
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Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.