Active ingredientPhenoxybenzamine HydrochlorideCat. No. P-P082-001CAS 63-92-3
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Pharmacopoeial impurity · Phenoxybenzamine family
Pharmaceutical analytical standardPhenoxybenzamine EP Impurity C
Synonyms: Phenoxybenzamine Impurity 7, N-(2-chloroethyl)-1-phenoxypropan-2-amine, Phenoxybenzamine impurity B, N-(2-Chloroethyl)-1-phenoxy-2-propanamine, Diethylamine, 2'-chloro-1-methyl-2-phenoxy-
- Cat. No.
- P-P082-004
- CAS
- 854881-53-1
- Alternative CAS
- 1824663-70-8 (hydrochloride)
- Formula
- C11H16ClNO
- Molecular weight
- 213.70 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Phenoxybenzamine
A non-selective, irreversible alpha-adrenergic blocker patented in the early 1950s; it is used to prepare patients with phaeochromocytoma, a tumour that releases adrenaline and noradrenaline, for surgery.
Did you know?It binds to the receptor with a covalent, permanent bond: its effect fades only when the body has made new receptors.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Phenoxybenzamine family
Active ingredientPhenoxybenzamine HydrochlorideCat. No. P-P082-001CAS 63-92-3
Pharmacopoeial impurityPhenoxybenzamine EP Impurity BCat. No. P-P082-002CAS 101-45-1
Pharmacopoeial impurityPhenoxybenzamine EP Impurity A HydrochlorideCat. No. P-P082-003CAS 1135069-65-6
Isotopically labelledPhenoxybenzamine-d5 HClCat. No. P-P082-005CAS 1329838-45-0
ImpurityPhenoxybenzamine Impurity 1 HydrochlorideCat. No. P-P082-006CAS 1135085-85-6
ImpurityDEA Derivatized PhenoxybenzamineCat. No. P-P082-007
ImpurityPhenoxybenzamine Impurity 2Cat. No. P-P082-008CAS 76805-26-0
ImpurityPhenoxybenzamine Impurity 3Cat. No. P-P082-009CAS 22881-33-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.